Abstract
The synthesis of thymidines selectively dansylated in the 3'- and 5'-positions is reported. The biological investigation showed that these fluorescent nucleosides behave as competitive inhibitors of thymidine kinase (TK) from herpes simplex virus (HSV) and are endowed with a certain degree of antiviral activity against HSV-2 and HSV-1.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Cells, Cultured
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Chemical Phenomena
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Chemistry
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Dansyl Compounds / chemical synthesis*
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Dansyl Compounds / pharmacology
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Simplexvirus / drug effects
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Spectrophotometry, Ultraviolet
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Thymidine / analogs & derivatives*
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Thymidine / chemical synthesis
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Thymidine / pharmacology
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Thymidine Kinase / antagonists & inhibitors
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Vaccinia virus / drug effects
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Vesicular stomatitis Indiana virus / drug effects
Substances
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Antiviral Agents
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Dansyl Compounds
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Thymidine Kinase
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Thymidine