High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence

Mol Microbiol. 2015 Apr;96(1):42-54. doi: 10.1111/mmi.12919. Epub 2015 Feb 11.

Abstract

Aspergillus fumigatus is a fungal pathogen that is capable of adapting to different host niches and to avoid host defenses. An enhanced understanding of how, and which, A. fumigatus signal transduction pathways are engaged in the regulation of these processes is essential for the development of improved disease control strategies. Protein phosphatases are central to numerous signal transduction pathways. To comprehend the functions of protein phosphatases in A. fumigatus, 32 phosphatase catalytic subunit encoding genes were identified. We have recognized PtcB as one of the phosphatases involved in the high osmolarity glycerol response (HOG) pathway. The ΔptcB mutant has both increased phosphorylation of the p38 MAPK (SakA) and expression of osmo-dependent genes. The ΔptcB strain was more sensitive to cell wall damaging agents, had increased chitin and β-1,3-glucan, and impaired biofilm formation. The ΔptcB strain was avirulent in a murine model of invasive pulmonary aspergillosis. These results stress the importance of the HOG pathway in the regulation of pathogenicity determinants and virulence in A. fumigatus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aspergillus fumigatus / genetics
  • Aspergillus fumigatus / pathogenicity*
  • Aspergillus fumigatus / physiology*
  • Aspergillus fumigatus / ultrastructure
  • Biofilms / growth & development
  • Cell Wall / metabolism
  • Chitin / metabolism
  • Computational Biology
  • Disease Models, Animal
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Glycerol / metabolism*
  • Mice
  • Mutation
  • Osmolar Concentration*
  • Phosphoric Monoester Hydrolases / genetics*
  • Phosphoric Monoester Hydrolases / metabolism
  • Signal Transduction
  • beta-Glucans / metabolism

Substances

  • Fungal Proteins
  • beta-Glucans
  • Chitin
  • beta-1,3-glucan
  • Phosphoric Monoester Hydrolases
  • Glycerol