Abstract
A novel type of dual pH-responsive supramolecular prodrug micelles based on host-guest interactions of water-soluble pillar[5]arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Calixarenes
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Doxorubicin / chemistry
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Doxorubicin / metabolism
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Drug Carriers / chemistry*
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Intracellular Space / metabolism*
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Micelles*
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Polyethylene Glycols / chemistry
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Prodrugs / chemistry*
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Prodrugs / metabolism*
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Quaternary Ammonium Compounds / chemistry*
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Solubility
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Water / chemistry
Substances
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Drug Carriers
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Micelles
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Prodrugs
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Quaternary Ammonium Compounds
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pillar(5)arene
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Water
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Calixarenes
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Polyethylene Glycols
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Doxorubicin