Abstract
Albicidin is a potent DNA gyrase inhibitor produced by the sugarcane pathogenic bacterium Xanthomonas albilineans. Here we report the elucidation of the hitherto unknown structure of albicidin, revealing a unique polyaromatic oligopeptide mainly composed of p-aminobenzoic acids. In vitro studies provide further insights into the biosynthetic machinery of albicidin. These findings will enable structural investigations on the inhibition mechanism of albicidin and its assessment as a highly effective antibacterial drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Aminobenzoic Acid / chemistry*
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Alanine / analogs & derivatives*
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Alanine / chemistry
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects
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Fermentation
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Microbial Sensitivity Tests
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Oligopeptides / chemistry
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Organic Chemicals / chemical synthesis
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Organic Chemicals / chemistry
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Organic Chemicals / pharmacology
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Structure-Activity Relationship
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Topoisomerase II Inhibitors / chemistry*
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Topoisomerase II Inhibitors / pharmacology*
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Xanthomonas / chemistry
Substances
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Anti-Bacterial Agents
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Oligopeptides
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Organic Chemicals
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Topoisomerase II Inhibitors
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3-cyanoalanine
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albicidin
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Alanine
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4-Aminobenzoic Acid
Associated data
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PubChem-Substance/223484021