In vitro susceptibility testing of eravacycline is unaffected by medium age and nonstandard assay parameters

Antimicrob Agents Chemother. 2015 Apr;59(4):2426-7. doi: 10.1128/AAC.04727-14. Epub 2015 Jan 20.

Abstract

Eravacycline is a fluorocycline antibiotic in phase 3 clinical development for complicated intra-abdominal and urinary tract infections. To support its clinical development, a study was conducted to evaluate the effects of various susceptibility test parameters on the MIC values for aerobic bacteria. The results showed that eravacycline appears to be largely unaffected by medium age, medium additives, and other nonstandard assay conditions.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria, Aerobic / drug effects*
  • Culture Media
  • Microbial Sensitivity Tests
  • Tetracyclines / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Culture Media
  • Tetracyclines
  • eravacycline