The family physician has a central role in preparing patients for transplantation and in the follow up. In the preoperative period adequate nutritional, vitamin intake and vaccinations are the mainstay of medical therapy. Pretransplant evaluation in a Liver Transplantation Centre is an essential part of the procedure, permitting an assessment of candidate's suitability and their position on the emergency list. During or immediately after the operation immunosuppression starts, according to personalized schedules and protocols. Among various complications, rejection must be promptly identified and treated. Resumption of a normal life style is the best indicator of a successful transplantation.