NF-κB is a master transcriptional regulator of inflammation that plays an important role in oncogenesis, particularly in tumors that arise in the context of inflammation. Copper metabolism MURR1 domain-containing 1 (COMMD1) is a negative regulator of NF-κB. Recent genetic-based studies in both mice and human patients indicate that COMMD1 has an important role in controlling intestinal inflammation and constraining progression to colitis-associated cancer.
Keywords: BMDM, bone marrow derived myeloid cells; CAC, colitis-associated cancer; COMMD1; COMMD1, copper metabolism MURR1 domain containing 1; GWAS, genome wide association studies; IBD, inflammatory bowel disease; IKK, IκB kinase; IκB, inhibitor of κB; K/O, knockout; LPS, lipopolysaccharide; Mye-K/O, myeloid-specific Commd1 knockout; NF-κB; NF-κB, nuclear factor-κB; SNP, single nucleotide polymorphism; WT, wild-type; colitis-associated cancer; inflammation; inflammatory bowel disease; ubiquitination.