1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain

Peng Sun; Qunfei Zhao; Zhuhua Wu; Wen Zhang; Wen Liu

doi:10.1021/np500468f

1,19-seco-Avermectin analogues from a ΔaveCDE mutant Streptomyces avermectinius strain

J Nat Prod. 2015 Feb 27;78(2):301-5. doi: 10.1021/np500468f. Epub 2015 Jan 22.

Authors

Peng Sun¹, Qunfei Zhao, Zhuhua Wu, Wen Zhang, Wen Liu

Affiliation

¹ Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University , 325 Guo-He Road, Shanghai 200433, People's Republic of China.

PMID: 25611131
DOI: 10.1021/np500468f

Abstract

Three new 1,19-seco-avermectin (AVE) analogues were isolated from the ΔaveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed spectroscopic analysis. This is the first report of 1,19-seco-AVE analogues. In an in vitro assay these compounds displayed cytotoxicity against Saos-2, MG-63, and B16 cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Drug Screening Assays, Antitumor
Humans
Ivermectin / analogs & derivatives*
Ivermectin / chemistry
Ivermectin / isolation & purification
Ivermectin / pharmacology
Mice
Molecular Structure
Mutation
Streptomyces / chemistry*
Streptomyces / genetics*

Substances

1,19-seco-avermectin
Antineoplastic Agents
Ivermectin
avermectin