It is important to recognize that patients with chest pain and a family history of cardiac diseases along with obvious risk factors might suffer from acute myocardial infarction. Even young females can be affected. We present a history of a 22-year-old woman who was predisposed to cardiac atherosclerosis. Her father and her brother had atherosclerotic changes in coronary arteries. Her BMI was 35 kg/m2 and she was a smoker. Her young age misled the physicians to conclude, with fatal consequence, that her symptoms with chest pain and heavy feeling in both arms were explained by spasms of the cardia.