An electrochemical peptide cleavage-based biosensor for prostate specific antigen detection via host-guest interaction between ferrocene and β-cyclodextrin

Shunbi Xie; Jin Zhang; Yali Yuan; Yaqin Chai; Ruo Yuan

doi:10.1039/c4cc10363g

An electrochemical peptide cleavage-based biosensor for prostate specific antigen detection via host-guest interaction between ferrocene and β-cyclodextrin

Chem Commun (Camb). 2015 Feb 25;51(16):3387-90. doi: 10.1039/c4cc10363g.

Authors

Shunbi Xie¹, Jin Zhang, Yali Yuan, Yaqin Chai, Ruo Yuan

Affiliation

¹ Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education (Southwest University), College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China. [email protected].

PMID: 25621734
DOI: 10.1039/c4cc10363g

Abstract

Here we have developed a "signal-on" peptide cleavage-based assay to directly transduce the peptide cleavage events into electrochemical signals via the host-guest interaction between ferrocene (Fc) and β-cyclodextrin (β-CD) for prostate specific antigen (PSA) detection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / methods*
Electrochemistry
Ferrous Compounds / chemistry*
Humans
Metallocenes
Peptides / chemistry*
Prostate-Specific Antigen / analysis*
beta-Cyclodextrins / chemistry*

Substances

Ferrous Compounds
Metallocenes
Peptides
beta-Cyclodextrins
Prostate-Specific Antigen
betadex
ferrocene