A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus

J D Chen; J F Hejtmancik; G Romeo; M Lindlof; C Boehm; C T Caskey; W Kress; K H Fischbeck; M Dreier; S Serravalle

doi:10.1016/0888-7543(89)90322-4

A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus

Genomics. 1989 Jan;4(1):105-9. doi: 10.1016/0888-7543(89)90322-4.

Authors

J D Chen¹, J F Hejtmancik, G Romeo, M Lindlof, C Boehm, C T Caskey, W Kress, K H Fischbeck, M Dreier, S Serravalle, et al.

Affiliation

¹ Prince of Wales Hospital, University of New South Wales, Sydney, Australia.

PMID: 2563349
DOI: 10.1016/0888-7543(89)90322-4

Abstract

Linkage analysis of five marker loci in and around the Duchenne muscular dystrophy (DMD) locus, DXS84, DXS206, DXS164, DXS270, and DXS28, was conducted with 499 families. Overall, the best multipoint distances were found to be DXS84-3.7 +/- 0.6 cM-DXS206-1.0 +/- 0.4 cM-DXS164-1.9 +/- 0.6 cM-DXS270-12.0 +/- 1.1 cM-DXS28. A comparison of this linkage map with the established physical map suggests the presence of hot spots for recombination in the DMD locus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Deletion
Chromosome Mapping
Female
Genetic Linkage
Genetic Markers
Humans
Male
Muscular Dystrophies / genetics*
Mutation
Polymorphism, Restriction Fragment Length
Recombination, Genetic
X Chromosome*

Substances

Genetic Markers