Full-genome sequencing of a Hungarian canine G3P[3] Rotavirus A strain reveals high genetic relatedness with a historic Italian human strain

Virus Genes. 2015 Apr;50(2):310-5. doi: 10.1007/s11262-014-1163-8. Epub 2015 Jan 30.

Abstract

A canine Rotavirus A strain was identified in the fecal specimen of a young dog during 2012 in Hungary. The strain RVA/Dog-wt/HUN/135/2012/G3P[3] shared complete genotype constellation (G3-P[3]-I3-R3-C3-M3-A15-N2-T3-E3-H6) and high genome sequence similarity (nt, 98.8 %) with a historic human strain, RVA/Human-tc/ITA/PA260-97/1997/G3P[3]. This study provides evidence for the canine origin of the unusual NSP1 genotype, A15, and reinforces the hypothesis of direct interspecies transmission of canine rotaviruses to humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Dog Diseases / virology*
  • Dogs
  • Genome, Viral*
  • Humans
  • Hungary
  • Italy
  • Molecular Sequence Data
  • Phylogeny
  • Rotavirus / chemistry
  • Rotavirus / classification
  • Rotavirus / genetics*
  • Rotavirus / isolation & purification*
  • Rotavirus Infections / veterinary*
  • Rotavirus Infections / virology*
  • Sequence Homology, Nucleic Acid
  • Viral Proteins / chemistry
  • Viral Proteins / genetics

Substances

  • Viral Proteins