RIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6

A M Api; D Belsito; S Bhatia; M Bruze; P Calow; M L Dagli; W Dekant; A D Fryer; L Kromidas; S La Cava; J F Lalko; A Lapczynski; D C Liebler; Y Miyachi; V T Politano; G Ritacco; D Salvito; J Shen; T W Schultz; I G Sipes; B Wall; D K Wilcox

doi:10.1016/j.fct.2015.01.005

RIFM fragrance ingredient safety assessment, Linalool, CAS registry number 78-70-6

Food Chem Toxicol. 2015 Aug:82 Suppl:S29-38. doi: 10.1016/j.fct.2015.01.005. Epub 2015 Jan 28.

Authors

A M Api¹, D Belsito², S Bhatia¹, M Bruze³, P Calow⁴, M L Dagli⁵, W Dekant⁶, A D Fryer⁷, L Kromidas⁸, S La Cava¹, J F Lalko¹, A Lapczynski¹, D C Liebler⁹, Y Miyachi¹⁰, V T Politano¹, G Ritacco¹, D Salvito¹, J Shen¹, T W Schultz¹¹, I G Sipes¹², B Wall¹, D K Wilcox¹

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677 USA.
² Member RIFM Expert Panel, Department of Dermatology, Columbia University Medical Center, 161 Fort Washington Ave., New York, NY 10032, USA.
³ Member RIFM Expert Panel, Department of Occupational & Environmental Dermatology, Malmo University Hospital, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden.
⁴ Member RIFM Expert Panel, University of Nebraska Lincoln, 230 Whittier Research Center, Lincoln, NE 68583-0857 USA.
⁵ Member RIFM Expert Panel, School of Veterinary Medicine and Animal Science, Department of Pathology, University of Sao Paulo, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
⁶ Member RIFM Expert Panel, Department of Toxicology, University of Wuerzburg, Versbacher Str. 9, Würzburg 97078, Germany.
⁷ Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239 USA.
⁸ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677 USA. Electronic address: [email protected].
⁹ Member RIFM Expert Panel, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
¹⁰ Member RIFM Expert Panel, Department of Dermatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
¹¹ Member RIFM Expert Panel, College of Veterinary Medicine, Department of Comparative Medicine, The University of Tennessee, 2407 River Dr., Knoxville, TN 37996-4500, USA.
¹² Member RIFM Expert Panel, Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.

PMID: 25637759
DOI: 10.1016/j.fct.2015.01.005

No abstract available

Publication types

Review

MeSH terms

Acyclic Monoterpenes
Animals
Consumer Product Safety*
DNA Damage / drug effects
Dose-Response Relationship, Drug
Endpoint Determination
Female
Humans
Male
Monoterpenes / chemistry
Monoterpenes / toxicity*
No-Observed-Adverse-Effect Level
Perfume / chemistry
Perfume / toxicity*
Rats
Risk Assessment
Toxicity Tests

Substances

Acyclic Monoterpenes
Monoterpenes
Perfume
linalool