Evidence that the genetic polymorphism rs1412115 on chromosome 10 is associated with risk for oral squamous cell carcinoma

Gene. 2015 Apr 15;560(2):137-9. doi: 10.1016/j.gene.2015.01.049. Epub 2015 Jan 29.

Abstract

A genome-wide association study on schizophrenia in Jewish population discovered a novel single nucleotide polymorphism (SNP), rs1412115, on chromosome 10. It has been proved that neuropilin-1 (NRP-1) gene located on chromosome 10, tightly close to rs1412115, is associated with increased risk for oral squamous cell carcinoma (OSCC). In the present study, we hypothesized that SNP rs1412115:A>G is associated with increased risk for OSCC. We therefore genotyped this polymorphism in 295 patients with OSCC and 594 cancer-free controls in the Chinese Han population, using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectroscopy. The pooled odds ratio was 1.42 (95% confidence interval [CI]=1.01-1.99, p=0.042) for carriers with the A version of the allele (AA and AG) compared with GG, and 1.46 (95% CI=1.02-2.09, p=0.036) for AG compared with GG. Our data provide evidence that the rs1412115: A>G polymorphism increases the risk of OSCC in Chinese Han populations. Larger population-based studies are needed to confirm these results.

Keywords: Genome-wide association study; Oral squamous cell carcinoma; Single nucleotide polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / genetics*
  • Case-Control Studies
  • Chromosomes, Human, Pair 10 / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors