Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery

Yannan Yang; Yuting Niu; Jun Zhang; Anand Kumar Meka; Hongwei Zhang; Chun Xu; Chun Xiang Cynthia Lin; Meihua Yu; Chengzhong Yu

doi:10.1002/smll.201402779

Biphasic Synthesis of Large-Pore and Well-Dispersed Benzene Bridged Mesoporous Organosilica Nanoparticles for Intracellular Protein Delivery

Small. 2015 Jun;11(23):2743-9. doi: 10.1002/smll.201402779. Epub 2015 Feb 4.

Authors

Yannan Yang¹, Yuting Niu¹, Jun Zhang¹, Anand Kumar Meka¹, Hongwei Zhang¹, Chun Xu¹, Chun Xiang Cynthia Lin¹, Meihua Yu¹, Chengzhong Yu¹

Affiliation

¹ Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.

PMID: 25652950
DOI: 10.1002/smll.201402779

Abstract

Large pore (4.6-7.6 nm) and well-dispersed benzene bridged mesoporous organosilica nanoparticles with uniform particle size of ≈50 nm are prepared via a biphasic approach. They can be directly used as nanocarriers without surface modification for the intracellular delivery of therapeutic proteins.

Keywords: biphasic synthesis; large pores; mesoporous organosilica nanoparticles; protein delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzene / chemistry*
Cross-Linking Reagents / chemistry
Delayed-Action Preparations / chemical synthesis
Diffusion
Drug Compounding / methods
Humans
MCF-7 Cells
Nanocapsules / administration & dosage
Nanocapsules / chemistry*
Nanocapsules / ultrastructure
Nanoconjugates / chemistry*
Nanoconjugates / ultrastructure
Nanopores / ultrastructure*
Organosilicon Compounds / chemistry*
Particle Size
Phase Transition
Porosity
Ribonuclease, Pancreatic / administration & dosage
Ribonuclease, Pancreatic / chemistry*

Substances

Cross-Linking Reagents
Delayed-Action Preparations
Nanocapsules
Nanoconjugates
Organosilicon Compounds
Ribonuclease, Pancreatic
Benzene