PPARγ and IL-6 - 174G>C gene variants in Croatian patients with ischemic stroke

Gene. 2015 Apr 15;560(2):200-4. doi: 10.1016/j.gene.2015.02.003. Epub 2015 Feb 7.

Abstract

Aim: Etiology of ischemic stroke (IS) is multifactorial and includes interaction of genetic and environmental factors. Different genes, their polymorphisms, host susceptibility, and inflammation processes play a role in IS development. The aim of this study was to evaluate the effect of PPAR-γ and IL-6 gene variants on IS onset.

Material and methods: A total of 301 subjects (144 males, 157 females) participated in the study, 114 patients with IS and 187 healthy controls.

Results: Statistically significant predictors of IS were male gender (OR 7.13, 95% CI 2.92-17.39, p<0.001), hypertension (OR 7.82. 95% CI 2.53-24.19, p<0.001), lowered HDL cholesterol (OR 8.20, 95% CI 2.41-27.94, p=0.001), elevated C-reactive protein (OR 5.26, 95% CI 1.92-14.41) and IL-6 -174 GC (OR 2.44 95% CI 1.01-5.91, p=0.0048) genotype. Males, compared to females, had 7 times higher odds for stroke. IL6 -174G/C genotype increased the odds for IS for 2.4 times. PPARγ was not statistically significantly associated with stroke.

Conclusion: We can point to the IL-6 -174G>C polymorphisms as candidate gene marker and risk factor for the prediction of ischemic stroke.

Keywords: Adults; Genes; Ischemic stroke; Polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Ischemia / genetics*
  • Case-Control Studies
  • Croatia
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Interleukin-6 / genetics*
  • Male
  • Middle Aged
  • PPAR gamma / genetics*
  • Polymorphism, Single Nucleotide
  • Risk Factors

Substances

  • IL6 protein, human
  • Interleukin-6
  • PPAR gamma