Cellular origin of prognostic chromosomal aberrations in AML patients

H Mora-Jensen; J Jendholm; N Rapin; M K Andersen; A S Roug; F O Bagger; L Bullinger; O Winther; N Borregaard; B T Porse; K Theilgaard-Mönch

doi:10.1038/leu.2015.30

Cellular origin of prognostic chromosomal aberrations in AML patients

Leukemia. 2015 Aug;29(8):1785-9. doi: 10.1038/leu.2015.30. Epub 2015 Feb 11.

Authors

H Mora-Jensen¹, J Jendholm², N Rapin³, M K Andersen⁴, A S Roug⁵, F O Bagger³, L Bullinger⁶, O Winther⁷, N Borregaard¹, B T Porse², K Theilgaard-Mönch⁸

Affiliations

¹ The Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
² 1] The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark [2] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark [3] Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
³ 1] The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark [2] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark [3] Danish Stem Cell Centre (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark [4] The Bioinformatics Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark.
⁴ The Cytogenetic Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
⁵ Department of Hematology, Aarhus University Hospital, University of Aarhus, Aarhus, Denmark.
⁶ Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany.
⁷ 1] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark [2] The Bioinformatics Centre, Department of Biology, Faculty of Natural Sciences, University of Copenhagen, Copenhagen, Denmark [3] DTU Compute, Technical University of Denmark, Lyngby, Denmark.
⁸ 1] The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark [2] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark [3] Department of Hematology, Skanes University Hospital, University of Lund, Lund, Sweden.

PMID: 25670329
DOI: 10.1038/leu.2015.30

No abstract available

Publication types

Comparative Study
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Chromosome Aberrations*
Chromosomes, Human, Pair 15 / genetics
Chromosomes, Human, Pair 17 / genetics
Flow Cytometry
Follow-Up Studies
Hematopoietic Stem Cells / metabolism
Hematopoietic Stem Cells / pathology*
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology*
Monocytes / metabolism
Monocytes / pathology*
Myeloid Cells / metabolism
Myeloid Cells / pathology*
Prognosis