Fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging has been widely used to diagnose many types of tumors. However, many factors can affect the accuracy of standardized uptake values (SUVs). In this study, we aimed to explore the applications of corrected SUVs in the diagnosis of peripheral solitary pulmonary lesions.A retrospective study was undertaken in 69 patients with peripheral solitary pulmonary lesions. Whole-body PET/CT was acquired approximately 60 min after F-FDG injection. The lesions were found to be malignant in 57 cases and benign in 12 cases. Of the 69 cases, 68 were correctly diagnosed, and only 1 was misdiagnosed by the corrected SUVs. The diagnostic accuracy rate was 98.5%. The sensitivity, specificity, positive predictive value, and negative predictive value of the corrected SUV were 100%, 91.7%, 98.3%, and 100%, respectively.F-FDG PET/CT with corrected SUVs is of great value for improving diagnostic accuracy in peripheral lung lesions.