Direct correlation between double K-RAS mutation and mucinous carcinoma. A case report

Appl Immunohistochem Mol Morphol. 2015 Feb;23(2):e4-7. doi: 10.1097/PAI.0000000000000176.

Abstract

Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Ras-dependent intracellular signals. Here we report a colon cancer case carrying a novel combination of K-RAS mutations involving codon 13 (Gly to Asp) and codon 19 (Leu to Phe), on separate alleles. The double mutation was restricted to tumor cells bearing a mucinous-like phenotype.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Mucinous / diagnosis*
  • Adenocarcinoma, Mucinous / drug therapy
  • Adenocarcinoma, Mucinous / pathology
  • Aged
  • Alleles
  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Biomarkers, Pharmacological / metabolism
  • Biomarkers, Tumor / genetics*
  • Cetuximab
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / drug therapy
  • Colonic Neoplasms / pathology
  • DNA Mutational Analysis
  • Drug Resistance, Neoplasm / genetics
  • Female
  • Genes, ras* / genetics
  • Humans
  • Mutation / genetics*
  • Panitumumab
  • Protein Kinase Inhibitors / therapeutic use

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Biomarkers, Pharmacological
  • Biomarkers, Tumor
  • Protein Kinase Inhibitors
  • Panitumumab
  • Cetuximab