Allelic variation at 5-HTTLPR is associated with brain morphology in a Chinese population

Jiewei Liu; Yin Mo; Tian Ge; Yi Wang; Xiong-jian Luo; Jianfeng Feng; Ming Li; Bing Su

doi:10.1016/j.psychres.2015.01.022

Allelic variation at 5-HTTLPR is associated with brain morphology in a Chinese population

Psychiatry Res. 2015 Mar 30;226(1):399-402. doi: 10.1016/j.psychres.2015.01.022. Epub 2015 Jan 30.

Authors

Jiewei Liu¹, Yin Mo², Tian Ge³, Yi Wang⁴, Xiong-jian Luo⁵, Jianfeng Feng³, Ming Li⁶, Bing Su⁷

Affiliations

¹ State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing, China.
² Imaging Center, The First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China.
³ Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China; Department of Computer Science, University of Warwick, Coventry, UK.
⁴ State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
⁵ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China.
⁶ Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, USA. Electronic address: [email protected].
⁷ State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. Electronic address: [email protected].

PMID: 25677398
DOI: 10.1016/j.psychres.2015.01.022

Abstract

Previous studies have reported significant associations of 5-HTTLPR with brain structures mainly in Europeans, but the situations in other ethnic groups remain largely unknown. Here we examined the association of 5-HTTLPR with regional gray matter volume in Han Chinese, and observed significant association in the postcentral gyrus and precuneus cortex.

Keywords: 5-HTTLPR; Han Chinese; VBM.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Amygdala / metabolism
Amygdala / physiology*
Asian People / ethnology*
Asian People / genetics*
Brain / anatomy & histology*
Brain / metabolism
Case-Control Studies
Female
Gene Frequency
Genetic Variation
Genetics, Population
Genotype
Gray Matter / anatomy & histology
Gray Matter / physiology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Polymerase Chain Reaction
Polymorphism, Genetic
Population Groups / genetics
Serotonin Plasma Membrane Transport Proteins / genetics*
Serotonin Plasma Membrane Transport Proteins / metabolism

Substances

SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins