Abstract
Primordial germ cells (PGCs) are the embryonic precursors of the germ cell lineage that form sperm and egg cells. It is of great importance to preserve the germline from DNA damage and potentially from epimutations in order to ensure the survival of future generations. Recent research highlights the role of the protein arginine methyltransferase 5 (PRMT5) as an important player in DNA protection during germline development in the mouse (Kim et al, & Li et al, 2015).
MeSH terms
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Animals
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Blastocyst / enzymology*
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Cell Differentiation / physiology*
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DNA Methylation*
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Epigenesis, Genetic / physiology*
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Female
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Gene Expression Regulation, Developmental / physiology*
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Genomic Instability*
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Germ Cells / cytology*
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Male
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Ovum / enzymology*
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Positive Regulatory Domain I-Binding Factor 1
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Protein Methyltransferases / metabolism
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Protein Methyltransferases / physiology*
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Protein-Arginine N-Methyltransferases
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Spermatozoa / enzymology*
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Transcription Factors / genetics*
Substances
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Prdm1 protein, mouse
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Transcription Factors
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Positive Regulatory Domain I-Binding Factor 1
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Protein Methyltransferases
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Prmt5 protein, mouse
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Protein-Arginine N-Methyltransferases