Men and women from the STRIDE clinical trial: An assessment of stimulant abstinence symptom severity at residential treatment entry

Am J Addict. 2015 Jun;24(4):336-40. doi: 10.1111/ajad.12190. Epub 2015 Feb 17.

Abstract

Background and objectives: Gender-specific factors associated with stimulant abstinence severity were examined in a stimulant abusing or dependent residential treatment sample (N = 302).

Method: Bivariate statistics tested gender differences in stimulant abstinence symptoms, measured by participant-reported experiences of early withdrawal. Multivariate linear regression examined gender and other predictors of stimulant abstinence symptom severity.

Results: Women compared to men reported greater stimulant abstinence symptom severity. Anxiety disorders and individual anxiety-related abstinence symptoms accounted for this difference. African American race/ethnicity was predictive of lower stimulant abstinence severity.

Discussion and conclusions: Women were more sensitive to anxiety-related stimulant withdrawal symptoms.

Scientific significance: Clinics that address anxiety-related abstinence symptoms, which more commonly occur in women, may improve treatment outcome.

Keywords: anxiety; early withdrawal symptoms; gender; stimulant abstinence severity.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Anxiety Disorders / chemically induced
  • Anxiety Disorders / diagnosis
  • Central Nervous System Stimulants / adverse effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Admission*
  • Residential Treatment*
  • Sex Factors
  • Substance Withdrawal Syndrome / diagnosis*
  • Substance-Related Disorders / drug therapy

Substances

  • Central Nervous System Stimulants