Association of the late cornified envelope-3 genes with psoriasis and psoriatic arthritis: a systematic review

Changbing Shen; Jing Gao; Xianyong Yin; Yujun Sheng; Liangdan Sun; Yong Cui; Xuejun Zhang

doi:10.1016/j.jgg.2015.01.001

Association of the late cornified envelope-3 genes with psoriasis and psoriatic arthritis: a systematic review

J Genet Genomics. 2015 Feb 20;42(2):49-56. doi: 10.1016/j.jgg.2015.01.001. Epub 2015 Jan 10.

Authors

Changbing Shen¹, Jing Gao², Xianyong Yin¹, Yujun Sheng¹, Liangdan Sun¹, Yong Cui¹, Xuejun Zhang³

Affiliations

¹ Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China.
² Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, China.
³ Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China; Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, China. Electronic address: [email protected].

PMID: 25697099
DOI: 10.1016/j.jgg.2015.01.001

Abstract

Psoriasis (Ps) and psoriatic arthritis (PsA) are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop (LCE) gene cluster, especially the cluster 3 (LCE3) genes. It is noteworthy that the deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future.

Keywords: LCE3 genes; Psoriasis; Psoriatic arthritis; Systematic review.

Publication types

Review
Systematic Review

MeSH terms

Arthritis, Psoriatic / genetics*
Arthritis, Psoriatic / metabolism
Cornified Envelope Proline-Rich Proteins / chemistry
Cornified Envelope Proline-Rich Proteins / genetics*
Cornified Envelope Proline-Rich Proteins / metabolism
Epistasis, Genetic
Genetic Association Studies*
Genetic Predisposition to Disease*
Genetic Variation
Humans
Multigene Family
Psoriasis / genetics*
Psoriasis / metabolism

Substances

Cornified Envelope Proline-Rich Proteins