Toward defining a 'lineage'--The case for dendritic cells

Leïla Perié; Shalin H Naik

doi:10.1016/j.semcdb.2015.02.004

Toward defining a 'lineage'--The case for dendritic cells

Semin Cell Dev Biol. 2015 May:41:3-8. doi: 10.1016/j.semcdb.2015.02.004. Epub 2015 Feb 17.

Authors

Leïla Perié¹, Shalin H Naik²

Affiliations

¹ Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Electronic address: [email protected].
² Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Electronic address: [email protected].

PMID: 25701440
DOI: 10.1016/j.semcdb.2015.02.004

Abstract

The immune system consists of a heterogeneous ensemble of cell types that immunologists have tried to classify and order for decades. This classification has relied on varying criteria, resulting in major debates in the immunology community. Discovered in the late 1970s [1], dendritic cells (DCs) are no exception, and their membership to a distinct immune lineage is still vividly debated [2-6]. Here, we review recent work on the origin of DCs and discuss the possible definition of a separate 'DC lineage'.

Keywords: Cellular barcoding; Dendritic cells; Immune cell types; Lineage; Lineage tracing; Mouse.

Publication types

Review

MeSH terms

Animals
Antigen Presentation / immunology*
Cell Lineage / immunology*
Dendritic Cells / immunology*
Dendritic Cells / metabolism
Humans
Models, Immunological
T-Lymphocytes / immunology*
fms-Like Tyrosine Kinase 3 / immunology
fms-Like Tyrosine Kinase 3 / metabolism

Substances

FLT3 protein, human
fms-Like Tyrosine Kinase 3