Simultaneous (18)F-FDOPA PET/CT-guided biopsy and radiofrequency ablation of recurrent neuroendocrine hepatic metastasis: further step toward a theranostic approach

Clin Nucl Med. 2015 Jun;40(6):e334-5. doi: 10.1097/RLU.0000000000000765.

Abstract

PET/CT-guided biopsy may be useful to confirm the metabolic findings when conventional imaging fails to show morphological abnormalities. Herein, we report the results of simultaneous F-FDOPA (fluorodihydroxyphenylalanine) PET/CT-guided biopsy and RFA (radiofrequency ablation) in 1 patient with hepatic metastatic evolution of a well-differentiated ileal neuroendocrine tumor. Beyond FDG, FDOPA could be successfully recommended in patients with neuroendocrine tumor for planning PET/CT-guided diagnostic biopsy, ablative treatment, and immediate efficacy assessment in a 1-step examination.

Publication types

  • Case Reports

MeSH terms

  • Ablation Techniques*
  • Dihydroxyphenylalanine / analogs & derivatives
  • Humans
  • Ileal Neoplasms / diagnostic imaging*
  • Ileal Neoplasms / pathology
  • Image-Guided Biopsy
  • Liver / pathology*
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery
  • Male
  • Middle Aged
  • Multimodal Imaging
  • Neuroendocrine Tumors / diagnostic imaging*
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / surgery
  • Positron-Emission Tomography*
  • Radiofrequency Therapy
  • Radiopharmaceuticals
  • Tomography, X-Ray Computed*

Substances

  • Radiopharmaceuticals
  • fluorodopa F 18
  • Dihydroxyphenylalanine