Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow

Melissa D Docampo; Jeffery J Auletta; Robert R Jenq

doi:10.1016/j.bbmt.2015.02.016

Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow

Biol Blood Marrow Transplant. 2015 Aug;21(8):1360-6. doi: 10.1016/j.bbmt.2015.02.016. Epub 2015 Feb 21.

Authors

Melissa D Docampo¹, Jeffery J Auletta², Robert R Jenq³

Affiliations

¹ Department of Immunology, Weill Cornell Graduate School of Medical Sciences, New York, New York. Electronic address: [email protected].
² Host Defense Program, Hematology/Oncology/BMT and Infectious Diseases, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio.
³ Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

PMID: 25708215
DOI: 10.1016/j.bbmt.2015.02.016

Abstract

The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.

Keywords: Antimicrobial peptide; Bacteremia; Bone marrow transplant; Clostridium difficile; Dysbiosis; Enterocyte; Graft-versus-host disease; Gut microbiota; IL-22; Paneth cell; Regenerating islet-derived III alpha; T cell; Tolerance.

Publication types

Review

MeSH terms

Gastrointestinal Microbiome / physiology*
Hematopoietic Stem Cell Transplantation / methods*
Humans
Microbiota / physiology*
Transplantation Conditioning / methods*
Transplantation, Homologous / methods*