Abstract
HIV genetic diversity is a major obstacle for vaccine development. To define whether potential T-cell epitope (PTE) peptide usage improves the detection of T cell responses in a highly diverse HIV-1 epidemic, we compared the magnitude, breadth and depth of group M PTE peptide responses to consensus M peptides in Gag and Nef proteins. Gag PTE responses were detected at a higher magnitude, more Nef PTE responses were detected at a cohort (but not individual) level and depth was detected in both Gag and Nef responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cameroon / epidemiology
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Epitopes, T-Lymphocyte / immunology*
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HIV Infections / epidemiology*
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HIV Infections / immunology*
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HIV Infections / virology
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HIV-1 / immunology*
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Humans
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Peptides / immunology
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T-Lymphocytes / immunology*
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gag Gene Products, Human Immunodeficiency Virus / immunology*
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nef Gene Products, Human Immunodeficiency Virus / immunology*
Substances
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Epitopes, T-Lymphocyte
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Peptides
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gag Gene Products, Human Immunodeficiency Virus
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nef Gene Products, Human Immunodeficiency Virus
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nef protein, Human immunodeficiency virus 1