Effect of graft perfusion with two CD45 monoclonal antibodies on incidence of kidney allograft rejection

Y Brewer; A Palmer; D Taube; K Welsh; M Bewick; C Bindon; G Hale; H Waldmann; F Dische; V Parsons

doi:10.1016/s0140-6736(89)90951-3

Effect of graft perfusion with two CD45 monoclonal antibodies on incidence of kidney allograft rejection

Lancet. 1989 Oct 21;2(8669):935-7. doi: 10.1016/s0140-6736(89)90951-3.

Authors

Y Brewer¹, A Palmer, D Taube, K Welsh, M Bewick, C Bindon, G Hale, H Waldmann, F Dische, V Parsons, et al.

Affiliation

¹ Renal Unit, Dulwich Hospital, London.

PMID: 2571860
DOI: 10.1016/s0140-6736(89)90951-3

Abstract

In a blind trial, 77 patients were randomised to receive first cadaver kidney allografts that had been perfused either with a pair of CD45 monoclonal antibodies (mAbs), in an attempt to reduce the immunogenicity of passenger leucocytes, or with control human albumin solution. No complications of mAb perfusion were observed. Patient and allograft survival were similar in both groups. Rejection episodes were recorded in 7 (18%) of the patient with mAb perfused allografts compared with 24 (63%) of the controls.

Publication types

Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Differentiation / administration & dosage*
Creatinine / blood
Dendritic Cells / metabolism
Evaluation Studies as Topic
Graft Rejection / drug effects*
Histocompatibility Antigens / administration & dosage*
Humans
Immunosuppression Therapy / methods
Incidence
Kidney Transplantation / methods*
Leukocyte Common Antigens
Perfusion / methods*
Premedication*
Randomized Controlled Trials as Topic
Rats
Transplantation, Homologous

Substances

Antigens, Differentiation
Histocompatibility Antigens
Creatinine
Leukocyte Common Antigens