Palladium-catalyzed coupling of azoles or thiazoles with aryl thioethers via C-H/C-S activation

Feng Zhu; Zhong-Xia Wang

doi:10.1021/acs.orglett.5b00510

Palladium-catalyzed coupling of azoles or thiazoles with aryl thioethers via C-H/C-S activation

Org Lett. 2015 Mar 20;17(6):1601-4. doi: 10.1021/acs.orglett.5b00510. Epub 2015 Feb 26.

Authors

Feng Zhu¹, Zhong-Xia Wang^{1

2}

Affiliations

¹ †CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
² ‡Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China.

PMID: 25719516
DOI: 10.1021/acs.orglett.5b00510

Abstract

Palladium-catalyzed cross-coupling via the C(sp(2))-S bond activation of aryl thioethers and the C-H bond activation of azoles or thiazoles was carried out. Electron-deficient and -rich aryl methyl thioethers and diaryl thioethers can be employed as the coupling partners and the reaction tolerates a range of functional groups including MeO, CF3, CN, PhCO, CONEt2, and Py groups.