ALT telomeres get together with nuclear receptors

Eric Aeby; Joachim Lingner

doi:10.1016/j.cell.2015.02.006

ALT telomeres get together with nuclear receptors

Cell. 2015 Feb 26;160(5):811-813. doi: 10.1016/j.cell.2015.02.006.

Authors

Eric Aeby¹, Joachim Lingner²

Affiliations

¹ Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
² Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: [email protected].

PMID: 25723159
DOI: 10.1016/j.cell.2015.02.006

Abstract

Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere insertions (TTI).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Genomic Instability*
Humans
Neoplasms / genetics*
Receptors, N-Methyl-D-Aspartate / metabolism*
Telomere / metabolism*

Substances

Receptors, N-Methyl-D-Aspartate