A Review and Proposed Approach to the Neutrophilic Dermatoses of Childhood

Kate Webb; Carol Hlela; H Francois Jordaan; Sara Suliman; Thomas Scriba; Dan Lipsker; Chris Scott

doi:10.1111/pde.12502

A Review and Proposed Approach to the Neutrophilic Dermatoses of Childhood

Pediatr Dermatol. 2015 Jul-Aug;32(4):437-46. doi: 10.1111/pde.12502. Epub 2015 Feb 26.

Authors

Kate Webb^{1

2}, Carol Hlela^{1

2}, H Francois Jordaan³, Sara Suliman⁴, Thomas Scriba⁴, Dan Lipsker⁵, Chris Scott¹

Affiliations

¹ Department of Rheumatology, University of Cape Town, Cape Town, South Africa.
² Department of Dermatology, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
³ Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Stellenbosch, Stellenbosch, South Africa.
⁴ South African TB Vaccine Initiative, University of Cape Town, Cape Town, South Africa.
⁵ Faculté de Médecine, Université de Strasbourg and Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

PMID: 25727235
DOI: 10.1111/pde.12502

Abstract

Neutrophilic dermatoses (NDs) are inflammatory skin conditions that are not associated with infection. The classification and clinical approach to these conditions in children is poorly described. This review classifies these conditions into five nosological subtypes: Sweet's syndrome, pyoderma gangrenosum, aseptic pustules, neutrophilic urticarial dermatoses, and Marshall's syndrome. In addition, we review the various secondary diseases that need to be excluded in the clinical management of the NDs of childhood, with a focus on the autoinflammatory conditions that the reader may not be familiar with. We propose a practical clinical approach to these disorders.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Abscess / classification
Abscess / diagnosis
Abscess / drug therapy
Cataract / classification
Cataract / diagnosis
Cataract / drug therapy
Child
Collagen Type XI / classification
Collagen Type XI / deficiency
Craniofacial Abnormalities / classification
Craniofacial Abnormalities / diagnosis
Craniofacial Abnormalities / drug therapy
Diagnosis, Differential
Hearing Loss, Sensorineural / classification
Hearing Loss, Sensorineural / diagnosis
Hearing Loss, Sensorineural / drug therapy
Humans
Neutrophil Infiltration*
Osteochondrodysplasias / classification
Osteochondrodysplasias / diagnosis
Osteochondrodysplasias / drug therapy
Pyoderma Gangrenosum / classification
Pyoderma Gangrenosum / diagnosis
Pyoderma Gangrenosum / drug therapy
Skin Diseases / classification*
Skin Diseases / diagnosis
Skin Diseases / drug therapy
Sweet Syndrome / classification
Sweet Syndrome / diagnosis
Sweet Syndrome / drug therapy
Urticaria / classification
Urticaria / diagnosis
Urticaria / drug therapy

Substances

Collagen Type XI

Supplementary concepts

Marshall syndrome