Microneedle biosensor for real-time electrical detection of nitric oxide for in situ cancer diagnosis during endomicroscopy

Do Hee Keum; Ho Sang Jung; Taejun Wang; Myeong Hwan Shin; Young-Eun Kim; Ki Hean Kim; G-One Ahn; Sei Kwang Hahn

doi:10.1002/adhm.201500012

Microneedle biosensor for real-time electrical detection of nitric oxide for in situ cancer diagnosis during endomicroscopy

Adv Healthc Mater. 2015 Jun 3;4(8):1153-8. doi: 10.1002/adhm.201500012. Epub 2015 Feb 27.

Authors

Do Hee Keum¹, Ho Sang Jung¹, Taejun Wang², Myeong Hwan Shin¹, Young-Eun Kim², Ki Hean Kim², G-One Ahn², Sei Kwang Hahn¹

Affiliations

¹ Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
² Department of Integrative Biosciences and Biotechnology, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.

PMID: 25728402
DOI: 10.1002/adhm.201500012

Abstract

A dual-diagnostic system of endom-icroscope and microneedle sensor is developed to demonstrate high-resolution imaging combined with electrical real-time detection of NO released from cancer tissues. The dual-diagnostic system can be a new platform for facile, precise, rapid, and accurate detection of cancers in various biomedical applications.

Keywords: PEDOT; biosensors; cancer diagnosis; microneedles; nitric oxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biosensing Techniques / methods*
Diagnostic Imaging
Disease Models, Animal
Image Processing, Computer-Assisted
Melanoma / diagnosis*
Mice
Needles
Nitric Oxide / analysis*
RAW 264.7 Cells

Substances

Nitric Oxide