An update on Sarcocystis neurona infections in animals and equine protozoal myeloencephalitis (EPM)

Vet Parasitol. 2015 Apr 15;209(1-2):1-42. doi: 10.1016/j.vetpar.2015.01.026. Epub 2015 Feb 7.

Abstract

Equine protozoal myeloencephalitis (EPM) is a serious disease of horses, and its management continues to be a challenge for veterinarians. The protozoan Sarcocystis neurona is most commonly associated with EPM. S. neurona has emerged as a common cause of mortality in marine mammals, especially sea otters (Enhydra lutris). EPM-like illness has also been recorded in several other mammals, including domestic dogs and cats. This paper updates S. neurona and EPM information from the last 15 years on the advances regarding life cycle, molecular biology, epidemiology, clinical signs, diagnosis, treatment and control.

Keywords: Epidemiology; Equine protozoal myeloencephalitis; Life cycle; Marine mammals; Prevention; Sarcocystis neurona.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Antiprotozoal Agents / therapeutic use
  • Encephalomyelitis / diagnosis
  • Encephalomyelitis / drug therapy
  • Encephalomyelitis / parasitology
  • Encephalomyelitis / pathology
  • Encephalomyelitis / veterinary*
  • Protozoan Infections, Animal / diagnosis
  • Protozoan Infections, Animal / drug therapy
  • Protozoan Infections, Animal / parasitology*
  • Protozoan Infections, Animal / pathology
  • Sarcocystis / classification*
  • Sarcocystosis / diagnosis
  • Sarcocystosis / drug therapy
  • Sarcocystosis / pathology
  • Sarcocystosis / veterinary*

Substances

  • Antiprotozoal Agents