Sarcopenia and fragility fractures: molecular and clinical evidence of the bone-muscle interaction

Umberto Tarantino; Eleonora Piccirilli; Massimo Fantini; Jacopo Baldi; Elena Gasbarra; Roberto Bei

doi:10.2106/JBJS.N.00648

Sarcopenia and fragility fractures: molecular and clinical evidence of the bone-muscle interaction

J Bone Joint Surg Am. 2015 Mar 4;97(5):429-37. doi: 10.2106/JBJS.N.00648.

Authors

Umberto Tarantino¹, Eleonora Piccirilli¹, Massimo Fantini², Jacopo Baldi¹, Elena Gasbarra¹, Roberto Bei²

Affiliations

¹ Department of Orthopaedics and Traumatology, University Hospital Foundation, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. E-mail address for U. Tarantino: [email protected].
² Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata," Via Montpellier 1, 00133 Rome Italy.

PMID: 25740034
DOI: 10.2106/JBJS.N.00648

Abstract

➤ Bone and muscle tissues are in close relationship, and the aging process is a factor involved in the loss of the functionality of both bones and muscles.➤ Sarcopenia and osteoporosis are linked from a biological and functional perspective and are related to an increased fracture risk in the elderly.➤ The increased fracture risk in sarcopenic and osteoporotic subjects is due to the decline of muscle mass and strength, the decrease in bone mineral density, and limited mobility.

Publication types

Review

MeSH terms

Absorptiometry, Photon
Accidental Falls / statistics & numerical data
Aging / pathology*
Aging / physiology*
Bone Density / physiology*
Bone and Bones / pathology
Bone and Bones / physiopathology
Comorbidity
Female
Humans
Male
Muscle Strength / physiology
Muscle, Skeletal / pathology
Osteoporosis / epidemiology*
Osteoporosis / pathology
Osteoporosis / physiopathology*
Prevalence
Sarcopenia / epidemiology*
Sarcopenia / pathology
Sarcopenia / physiopathology*