Multilevel BCR signals toward CLL

Blood. 2015 Mar 5;125(10):1510-2. doi: 10.1182/blood-2015-01-621227.

Abstract

In this issue of Blood, Iacovelli et al provide the first in vivo experimental evidence on the proleukemogenic relevance of autonomous (exo-antigen–independent) B-cell receptor (BCR) stimulation in conjunction with ligand (autoantigen)- mediated BCR signaling in chronic lymphocytic leukemia (CLL).

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / etiology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Receptors, Antigen, B-Cell / metabolism*

Substances

  • Receptors, Antigen, B-Cell