[Therapy of resistant duodenal ulcer]

Minerva Med. 1989 Nov;80(11):1205-10.
[Article in Italian]

Abstract

Significant progress has been made in the treatment of duodenal ulcers since cimetidine went on the market. Furthermore widespread use of the H2 blockers has enable us to identify a group of patients who take 8-12 weeks to heal, despite effective treatment and who are now known as "slow" or non-responders. In tackling the problem of ulcers resistant to medical treatment, the paper details the possibilities offered by current solutions on the basis of personal experience as well as reports in the literature. The results obtainable by surgery are also assessed with emphasis on the identification of suitable patients for and the appropriate timing of his surgical option. Finally a therapeutic flow-chart providing guidelines for the rational selection of therapeutic strategies that still had to be based on uncodified personal preferences is proposed.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Anti-Ulcer Agents / therapeutic use*
  • Drug Therapy, Combination
  • Duodenal Ulcer / drug therapy
  • Duodenal Ulcer / surgery
  • Duodenal Ulcer / therapy*
  • Follow-Up Studies
  • Histamine H2 Antagonists / administration & dosage
  • Histamine H2 Antagonists / therapeutic use*
  • Humans
  • Parasympatholytics / administration & dosage
  • Parasympatholytics / therapeutic use*
  • Recurrence
  • Time Factors
  • Vagotomy, Proximal Gastric
  • Vagotomy, Truncal

Substances

  • Anti-Ulcer Agents
  • Histamine H2 Antagonists
  • Parasympatholytics