A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone

C N Hahn; D M Ross; J Feng; A Beligaswatte; D K Hiwase; W T Parker; M Ho; M Zawitkowski; K L Ambler; G D Cheetham; Y K Lee; M Babic; C M Butcher; G A Engler; A L Brown; R J D'Andrea; I D Lewis; A W Schreiber; L B To; H S Scott

doi:10.1038/leu.2015.67

A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone

Leukemia. 2015 Oct;29(10):2101-4. doi: 10.1038/leu.2015.67. Epub 2015 Mar 9.

Authors

C N Hahn^{1

2

3

4}, D M Ross^{3

5

6}, J Feng⁷, A Beligaswatte^{5

6}, D K Hiwase⁵, W T Parker^{1

2

4}, M Ho¹, M Zawitkowski¹, K L Ambler¹, G D Cheetham¹, Y K Lee¹, M Babic¹, C M Butcher⁵, G A Engler⁵, A L Brown^{2

4

5}, R J D'Andrea^{2

4

5}, I D Lewis^{3

5}, A W Schreiber^{7

8}, L B To^{3

5}, H S Scott^{1

2

3

4

8}

Affiliations

¹ Department of Molecular Pathology, SA Pathology, Adelaide, Australia.
² Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
³ School of Medicine, University of Adelaide, Adelaide, Australia.
⁴ School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
⁵ Department of Haematology, SA Pathology, Adelaide, Australia.
⁶ Flinders University and Medical Centre, Adelaide, Australia.
⁷ ACRF South Australian Cancer Genomics Facility, Centre for Cancer Biology, SA Pathology, Adelaide, Australia.
⁸ School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia.

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA (Cytosine-5-)-Methyltransferases / genetics*
DNA Methyltransferase 3A
Humans
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Mutation / genetics*
Preleukemia / genetics*
Prognosis
Siblings*

Substances

DNMT3A protein, human
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A