Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases

J Allergy Clin Immunol. 2015 Aug;136(2):495-7. doi: 10.1016/j.jaci.2015.01.022. Epub 2015 Mar 7.

Authors

Affiliations

¹ Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany. Electronic address: [email protected].
² Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany.
³ Department of Metabolomics, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany.
⁴ Department of Proteomics, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany.
⁵ UFZ-Helmholtz Centre for Environmental Research Leipzig, Core Facility Studies, Leipzig, Germany.
⁶ Institute for Clinical Immunology, University of Leipzig, Leipzig, Germany.
⁷ Universitätsklinikum, Klinik für Dermatologie, Venerologie und Allergologie, Leipzig, Germany.
⁸ Children's Hospital, Municipal Hospital "St. Georg," Academic Teaching Hospital of the University of Leipzig, Leipzig, Germany.
⁹ Department of Proteomics, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany; Department of Biotechnology, Chemistry, and Environmental Engineering, Aalborg University, Sohngaardsholmsvej, Aalborg, Denmark.
¹⁰ Department of Environmental Immunology, UFZ-Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany. Electronic address: [email protected].

PMID: 25754623
DOI: 10.1016/j.jaci.2015.01.022

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Asthma / blood*
Asthma / diagnosis
Asthma / immunology
Asthma / pathology
Blood Glucose / immunology
Blood Glucose / metabolism
Bronchitis / blood*
Bronchitis / diagnosis
Bronchitis / immunology
Bronchitis / pathology
Carrier Proteins / blood
Carrier Proteins / genetics
Carrier Proteins / immunology
Caspase 1 / blood
Caspase 1 / genetics
Caspase 1 / immunology
Child, Preschool
Dermatitis, Atopic / blood*
Dermatitis, Atopic / diagnosis
Dermatitis, Atopic / immunology
Dermatitis, Atopic / pathology
Fatty Acids / blood
Fatty Acids / immunology
Female
Gene Expression
Humans
Immunoglobulin E / blood
Immunoglobulin E / genetics
Infant
Inflammasomes / genetics
Inflammasomes / immunology*
Interleukin-18 / blood
Interleukin-18 / genetics
Interleukin-18 / immunology
Interleukin-1beta / blood*
Interleukin-1beta / genetics
Interleukin-1beta / immunology
Male
Metabolome
Myeloid Differentiation Factor 88 / blood
Myeloid Differentiation Factor 88 / genetics
Myeloid Differentiation Factor 88 / immunology
NLR Family, Pyrin Domain-Containing 3 Protein
Phospholipids / blood
Phospholipids / immunology
Prognosis
Respiratory Hypersensitivity / blood*
Respiratory Hypersensitivity / diagnosis
Respiratory Hypersensitivity / immunology
Respiratory Hypersensitivity / pathology
Rhinitis, Allergic, Seasonal / blood*
Rhinitis, Allergic, Seasonal / diagnosis
Rhinitis, Allergic, Seasonal / immunology
Rhinitis, Allergic, Seasonal / pathology
Toll-Like Receptors / blood
Toll-Like Receptors / genetics
Toll-Like Receptors / immunology
Twins

Substances

Blood Glucose
Carrier Proteins
Fatty Acids
IL18 protein, human
Inflammasomes
Interleukin-18
Interleukin-1beta
MYD88 protein, human
Myeloid Differentiation Factor 88
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human
Phospholipids
Toll-Like Receptors
Immunoglobulin E
Caspase 1