An infant with a diagnostically challenging hepatic teratoma, hypofibrinogenemia, and adrenal neuroblastoma: case report

Pediatr Dev Pathol. 2015 May-Jun;18(3):251-6. doi: 10.2350/13-08-1361-CR.1. Epub 2015 Mar 10.

Abstract

Teratomas of the liver are exceedingly rare. Neuroblastoma is the most common, extracranial solid tumor of infancy. We describe the case of a 2-month-old, female infant who presented with an abdominal mass arising in the right lobe of the liver, and a severe coagulopathy, which necessitated cryoprecipitate infusion. Biopsy was interpreted as hepatoblastoma. Following resection, difficulty classifying the mass led to several consultations, and an eventual diagnosis of teratoma. During follow-up, the patient was diagnosed with right adrenal neuroblastoma, which, in retrospect, had been present before the hepatic resection. To our knowledge, these 2 tumors have never been reported together, or in combination with isolated hypofibrinogenemia.

Keywords: hepatoblastoma; hypofibrinogenemia; liver tumor; neuroblastoma; teratoma.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms / pathology*
  • Afibrinogenemia / complications
  • Afibrinogenemia / congenital*
  • Female
  • Humans
  • Infant
  • Liver Neoplasms / pathology*
  • Neoplasms, Multiple Primary / pathology*
  • Neuroblastoma / pathology*
  • Teratoma / pathology*