Sustained cytopenia after leukapheresis for collection of peripheral blood stem cells in small children

Vox Sang. 1989;57(3):168-71. doi: 10.1111/j.1423-0410.1989.tb00816.x.

Abstract

Marked and persistent cytopenia was observed in two 3-year-old children with cancer, after lymphopheresis to collect peripheral blood stem cells (PBSC) for autotransplantation after high-dose chemotherapy. This finding suggests that PBSC are a major component of the hematopoietic cells in small children and, hence, that special care is necessary in the construction of a protocol for collection of stem cells from young children.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Clinical Protocols
  • Female
  • Hematopoiesis / physiology
  • Hematopoietic Stem Cell Transplantation*
  • Hematopoietic Stem Cells / physiology
  • Humans
  • Leukapheresis / adverse effects*
  • Leukemia, T-Cell / drug therapy
  • Leukemia, T-Cell / therapy*
  • Leukopenia / etiology*
  • Male
  • Neuroblastoma / drug therapy
  • Neuroblastoma / therapy*
  • Recurrence