Abstract
We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overlapping mutational signatures highlighting the degree of heterogeneity between multiple specimens in the same patient. Observations in these cases imply that considering not only the number of mutations but an effective oncogenic combination of mutations can determine the malignant progression of colorectal lesions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / genetics*
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Adenocarcinoma / pathology
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Adenoma / genetics*
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Adenoma / pathology
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Aged
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Aged, 80 and over
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Clonal Evolution*
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / pathology
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Female
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Humans
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Male
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Mutation*
Grants and funding
Funding provided by Grant PI12/00357 (isciii, FEDER funds) to JPV, Grant Fundación Aecc to MAP, Grant SODERCAN-Gobierno de Cantabria to MAP and Grant from the Spanish “Ministerio de Ciencia e Innovación” (RETICS, SAF2008-03871)to MAP. IV is funded by Spanish Ministerio de Economía y Competitividad subprograma Ramón y Cajal. The authors would like to thank Servicio Santander Supercomputación for their IT support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.