Mitochondrial permeability transition pore (MPTP)-dependent and -independent pathways of mitochondrial membrane depolarization, cell shrinkage and microparticle formation during platelet apoptosis

Br J Haematol. 2015 Apr;169(1):142-5. doi: 10.1111/bjh.13180. Epub 2014 Oct 10.

Authors

Armen V Gyulkhandanyan¹, Asuman Mutlu, John Freedman, Valery Leytin

Affiliation

¹ Toronto Platelet Immunobiology Group, St. Michael's Hospital, Toronto, ON, Canada; The Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.

PMID: 25776535
DOI: 10.1111/bjh.13180

No abstract available

Keywords: apoptosis; depolarization; mitochondria; permeabilization; platelets.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / physiology*
Blood Platelets / metabolism*
Cell-Derived Microparticles / metabolism*
Humans
Membrane Potential, Mitochondrial / physiology*
Mitochondrial Membrane Transport Proteins / metabolism*
Mitochondrial Membranes / metabolism*
Mitochondrial Permeability Transition Pore

Substances

Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore