A novel Alzheimer disease locus located near the gene encoding tau protein

Affiliations

• ¹ Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
• ² Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA.
• ³ Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
• ⁴ Department of Epidemiology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands.
• ⁵ Department of Neurology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands.
• ⁶ Institute of Psychological Medicine and Clinical Neurosciences, Medical Research Council (MRC) Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
• ⁷ Inserm U744, Lille, France.
• ⁸ Université Lille 2, Lille, France.
• ⁹ Institut Pasteur de Lille, Lille, France.
• ¹⁰ Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
• ¹¹ The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
• ¹² Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• ¹³ Trinity College, University of Dublin, Dublin, Ireland.
• ¹⁴ Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
• ¹⁵ University of Iceland, Faculty of Medicine, Reykjavik, Iceland.
• ¹⁶ Icelandic Heart Association, Kopavogur, Iceland.
• ¹⁷ Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
• ¹⁸ Netherlands Consortium for Healthy Aging, Leiden, The Netherlands.
• ¹⁹ Department of Radiology, Erasmus University Medical Center, Erasmus, Rotterdam,The Netherlands.
• ²⁰ Institute for Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.
• ²¹ Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, Riken, Kanagawa, Japan.
• ²² Foundation Jean Dausset-CEPH, Paris, France.
• ²³ Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
• ²⁴ Centre National de Genotypage, Institut Genomique, Commissariat a l'energie Atomique, Evry, France.
• ²⁵ Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
• ²⁶ Institute of Human Genetics, University of Bonn, Bonn, Germany.
• ²⁷ Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
• ²⁸ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
• ²⁹ Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
• ³⁰ Department of Epidemiology, University of Washington, Seattle, WA, USA.
• ³¹ Centre National de Reference pour les Malades Alzheimer Jeunes (CNR-MAJ), Centre Hospitalier Régional Universitaire de Lille, Lille, France.
• ³² Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA.
• ³³ Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
• ³⁴ National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
• ³⁵ Departments of Health Services, University of Washington, Seattle, WA, USA.
• ³⁶ Department of Geriatrics, University Paris Descartes, Sorbonne Paris V, France.
• ³⁷ Geriatrics Department, Broca Hospital, Paris, France.
• ³⁸ Mercer's Institute for Research on Aging, St James Hospital and Trinity College, Dublin, Ireland.
• ³⁹ Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
• ⁴⁰ CNR-MAJ, Inserm U1079, Rouen, France; University Hospital, 76031 Rouen, France.
• ⁴¹ University of Bristol Institute of Clinical Neurosciences, School of Clinical Sciences, Frenchay Hospital, Bristol, UK.
• ⁴² Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
• ⁴³ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
• ⁴⁴ Inserm U888, Hôpital La Colombière, Montpellier, France.
• ⁴⁵ Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
• ⁴⁶ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.
• ⁴⁷ Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
• ⁴⁸ Departments of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
• ⁴⁹ University of Pittsburgh Alzheimer's Disease Research Center, Pittsburgh, PA, USA.
• ⁵⁰ Departments of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
• ⁵¹ Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.
• ⁵² Inserm U897, Victor Segalen University, F-33076, Bordeaux, France.
• ⁵³ Department of Molecular Neuroscience, Institute of Neurology, London, UK.
• ⁵⁴ Reta Lilla Weston Laboratories, Institute of Neurology, London, UK.
• ⁵⁵ Department of Medicine, University of Washington, Seattle, WA, USA.
• ⁵⁶ Oxford Healthy Aging Project (OHAP), Clinical Trial Service Unit, University of Oxford, Oxford, UK.
• ⁵⁷ Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
• ⁵⁸ Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA.
• ⁵⁹ Institute of Public Health, University of Cambridge, Cambridge, UK.
• ⁶⁰ Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology and Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
• ⁶¹ Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
• ⁶² Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland.
• ⁶³ Centre de Mémoire de Ressources et de Recherche de Bordeaux, CHU de Bordeaux, Bordeaux, France.
• ⁶⁴ Department of Psychiatry, University of Frankfurt, Frankfurt am Main, Germany.
• ⁶⁵ Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
• ⁶⁶ Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
• ⁶⁷ Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra School of Medicine, Pamplona, Spain.
• ⁶⁸ CIBERNED, Instituto de Salud Carlos III, Madrid, Spain.
• ⁶⁹ Group Health, Group Health Research Institute, Seattle, WA, USA.
• ⁷⁰ Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
• ⁷¹ Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
• ⁷² Department of Pathology, University of Washington, Seattle, WA, USA.
• ⁷³ Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA.
• ⁷⁴ Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
• ⁷⁵ Department of Psychiatry, University of Arizona, Phoenix, AZ, USA.
• ⁷⁶ Banner Alzheimer's Institute, Phoenix, AZ, USA.
• ⁷⁷ Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona.
• ⁷⁸ Department of Geriatrics, Landspitali National University Hospital, Reykjavik, Iceland.
• ⁷⁹ Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
• ⁸⁰ Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada.
• ⁸¹ Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
• ⁸² Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
• ⁸³ PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
• ⁸⁴ Department of Neurology, Medical University of Graz, Graz, Austria.
• ⁸⁵ Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
• ⁸⁶ King's College London, Institute of Psychiatry, Department of Neuroscience, De Crespigny Park, Denmark Hill, London, UK.
• ⁸⁷ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
• ⁸⁸ Department of Biology, Brigham Young University, Provo, Utah, USA.
• ⁸⁹ Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
• ⁹⁰ Department of Psychiatry, Psychotherapy and Psychosomatics Martin-Luther-University Halle-Wittenberg, Halle, Germany.
• ⁹¹ Institute of Human Genetics, Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
• ⁹² Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
• ⁹³ Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.
• ⁹⁴ Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
• ⁹⁵ Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA.
• ⁹⁶ Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
• ⁹⁷ Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
• ⁹⁸ Department of Neurology, Columbia University, New York, NY, USA.
• ⁹⁹ McGill University and Génome Québec Innovation Centre, Montreal, QC, Canada.
• ¹⁰⁰ University Hospital, CHRU Lille, Lille, France.
• ¹⁰¹ Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.