PLEKHA5: A Key to Unlock the Blood-Brain Barrier?

Sylvia C Eisele; Corey M Gill; Ganesh M Shankar; Priscilla K Brastianos

doi:10.1158/1078-0432.CCR-14-2604

PLEKHA5: A Key to Unlock the Blood-Brain Barrier?

Clin Cancer Res. 2015 May 1;21(9):1978-80. doi: 10.1158/1078-0432.CCR-14-2604. Epub 2015 Mar 16.

Authors

Sylvia C Eisele¹, Corey M Gill¹, Ganesh M Shankar², Priscilla K Brastianos³

Affiliations

¹ Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
² Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
³ Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. [email protected].

PMID: 25779946
DOI: 10.1158/1078-0432.CCR-14-2604

Abstract

Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Brain Neoplasms / genetics*
Brain Neoplasms / secondary*
Female
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Male
Melanoma / genetics*
Melanoma / secondary*

Substances

Intracellular Signaling Peptides and Proteins

Grants and funding

K12CA090354/CA/NCI NIH HHS/United States