Highly enantioselective [3 + 2]-annulation of isatin-derived morita-baylis-hillman adducts with cyclic sulfonimines

Org Lett. 2015 Apr 3;17(7):1688-91. doi: 10.1021/acs.orglett.5b00456. Epub 2015 Mar 17.

Abstract

An organocatalytic [3 + 2]-annulation between isatin-derived Morita-Baylis-Hillman adducts and cyclic sulfonimines has been developed in high yields with excellent enantio- and diastereoselectivities via an allylic nitrogen-ylide intermediate. The reaction provides access to heavily substituted aza-spirooxindole derivatives, which also contain ring fused cyclic sultams.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Isatin / chemistry*
  • Molecular Structure
  • Stereoisomerism
  • Sulfhydryl Compounds / chemistry*

Substances

  • Sulfhydryl Compounds
  • Isatin