Freshly emerged virgin female Sarcophaga ruficornis were topically treated with different doses of pyriproxyfen to test the efficacy on reproduction and subsequent F1 progeny. The results included mortality of the treated adults, significant reduction in fecundity, more than 90% inhibition in larvae production, mortality in F1 generation during larval instars, reduction in pupariation, and adult emergence and production of deformed adults. There was a dose-dependent response showing high degree of correlation in the doses administered and deformities observed. The effects in F1 generation show that an intraovarial transfer of pyriproxyfen was responsible for the various deformations observed, showing the potency of juvenoid pyriproxyfen for longer durations across generations. This is the first study that clearly demonstrates the efficacy of pyriproxyfen against reproduction in S. ruficornis and its potential for the management of this notorious pest of medico-veterinary importance.