Abstract
Surfactants induce fusion (or increase in size) of sonicated liposomes. This phenomenon is enhanced by cholesterol and inhibited by the intrinsic polypeptide gramicidin A. By comparison with previous physical studies we conclude that liposome 'fusion' is facilitated when both fluidity and static order of the bilayer are high.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholesterol / pharmacology
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Dimyristoylphosphatidylcholine
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Gramicidin / pharmacology
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Lipid Bilayers*
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Liposomes*
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Membrane Fluidity*
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Membrane Fusion / drug effects*
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Octoxynol
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Polyethylene Glycols / pharmacology*
Substances
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Lipid Bilayers
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Liposomes
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Gramicidin
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Polyethylene Glycols
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Octoxynol
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Cholesterol
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Dimyristoylphosphatidylcholine