CD5 helps aspiring regulatory T cells ward off unwelcome cytokine advances

Amy C Palin; Paul E Love

doi:10.1016/j.immuni.2015.02.018

CD5 helps aspiring regulatory T cells ward off unwelcome cytokine advances

Immunity. 2015 Mar 17;42(3):395-6. doi: 10.1016/j.immuni.2015.02.018.

Authors

Amy C Palin¹, Paul E Love²

Affiliations

¹ Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
² Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: [email protected].

PMID: 25786168
DOI: 10.1016/j.immuni.2015.02.018

Abstract

The role of co-receptor molecules in the generation of inducible regulatory T cells (iTregs) remains incompletely defined. In this issue of Immunity, Henderson et al. (2015) show that CD5 regulates iTreg cell induction by rendering emerging iTreg cells refractory to signals mediated by effector-differentiating cytokines.

Publication types

Comment

MeSH terms

Animals
Autoantigens / immunology*
CD5 Antigens / immunology*
T-Lymphocytes, Regulatory / metabolism*

Substances

Autoantigens
CD5 Antigens
Cd5 protein, mouse