Abstract
A novel synthetic approach to functionalized indolo[2,3-a]quinolizidines is developed via an N-heterocyclic carbene (NHC)-catalyzed annulation of cyclic β-enamino esters with enals . This methodology offers a pathway for quick and efficient construction of an indolo[2,3-a]quinolizidine skeleton which is a core structure of many natural products with diverse bioactivities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Carbon / chemistry
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Catalysis
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Chemistry, Pharmaceutical
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Chromatography, Thin Layer
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Esters / chemistry*
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Heterocyclic Compounds / chemistry
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Indoles / chemistry
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Light
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Quinolizidines / chemistry
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Solvents / chemistry
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Stereoisomerism
Substances
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Aldehydes
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Esters
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Heterocyclic Compounds
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Indoles
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Quinolizidines
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Solvents
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carbene
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Carbon
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Methane