Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential

Adv Healthc Mater. 2015 Jun 3;4(8):1175-9. doi: 10.1002/adhm.201500053. Epub 2015 Mar 19.

Abstract

Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.

Keywords: articular cartilage; collagen-based scaffolds; growth factor delivery; mesenchymal stem cells; transforming growth factor-beta 3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggrecans / genetics
  • Aggrecans / metabolism
  • Animals
  • Biocompatible Materials / chemistry
  • Cell Differentiation
  • Cells, Cultured
  • Chondrogenesis*
  • Collagen / chemistry*
  • Collagen Type II / genetics
  • Collagen Type II / metabolism
  • Glycosaminoglycans / chemistry
  • Hyaluronic Acid / chemistry*
  • Mesenchymal Stem Cells / metabolism
  • Protein Conformation
  • Rats
  • SOX Transcription Factors / genetics*
  • SOX Transcription Factors / metabolism
  • Serum Albumin, Bovine / chemistry
  • Tissue Engineering
  • Tissue Scaffolds*
  • Transforming Growth Factor beta3 / chemistry*

Substances

  • Acan protein, rat
  • Aggrecans
  • Biocompatible Materials
  • COL2A1 protein, rat
  • Collagen Type II
  • Glycosaminoglycans
  • SOX Transcription Factors
  • Transforming Growth Factor beta3
  • collagen-glycosaminoglycan copolymer
  • Serum Albumin, Bovine
  • Hyaluronic Acid
  • Collagen